在C反应性蛋白-白蛋白-淋巴细胞指数和心血管疾病之间的负相关性
Shuaiqing Chen1, Mingshen Lin2, Jing Ye1
1Department of Cardiology, Lishui Hospital of Traditional Chinese Medicine, China.
The Journal of international medical research
|February 16, 2026
概括
反应性C蛋白-白蛋白-淋巴细胞 (CALLY) 指数显示,与心血管疾病患病率和死亡率有显著的反向关联. 较高的CALLY指数得分与降低心血管疾病风险和成人更好的预后有关.
科学领域:
- 心血管医学 心血管医学
- 生物标志物研究 生物标志物研究
- 公共卫生 公共卫生
背景情况:
- 在一般人群中,对心血管疾病 (CVD) 的C-反应蛋白-白蛋白-淋巴细胞 (CALLY) 指数的预后作用需要进一步研究.
- 目前对CALLY指数对心血管疾病预测能力的研究是有限的.
研究的目的:
- 评估CALLY指数与心血管疾病的患病率和死亡率之间的关联.
- 评估CALLY指数在预测大量成年人队列中心血管疾病结果中的有用性.
主要方法:
- 分析了1999-2010年间22848名成年人的数据.
- 用多变量逻辑回归和考克斯比例危险模型来检查关联.
- 限制立方线,卡普兰-梅尔曲线和时间依赖的ROC曲线被用于全面分析.
主要成果:
- 在ln CALLY指数上升1个单位与心血管疾病发病率下降11% (OR=0.89) 和心血管疾病死亡风险下降15% (HR=0.85) 相相关.
- 与最低四分位数相比,最高CALLY指数四分位数显示心脏病发病率降低33%,心脏病死亡风险降低39%.
- 在In CALLY指数显示强大的预测能力为1年心血管疾病死亡率 (AUC=0.819).
结论:
- 卡利指数与心血管疾病患病率和死亡率有显著的反向关联.
- 卡利指数证明了可靠的区分能力,用于预测早期心血管疾病死亡率.
- 卡利指数作为一个有价值的预后生物标志物,用于心血管疾病的结果.
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