瘤有机体研究的进展和应用 利用人类瘤有机体用于癌症建模和精密治疗
Tonghai Zhou1,2, Qianyi Wang1,2, Meili Zhang1,2
1State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Protein & cell
|February 16, 2026
概括
人类瘤器官通过准确模拟患者瘤,正在彻底改变癌症研究. 这些先进的模型改善了药物查和个性化医疗,弥合了发现和临床应用之间的差距.
科学领域:
- 生物医学工程 生物医学工程
- 癌症研究 癌症研究
- 有机物技术 有机物技术
背景情况:
- 传统的癌症模型缺乏患者的瘤复杂性.
- 人类瘤有机体忠实地回顾了瘤异质性和微环境.
- 器官仪器是基础研究和临床翻译之间的桥梁.
研究的目的:
- 审查人类瘤有机体生成和应用方面的进展.
- 探索技术创新,以提高可解释性和可翻译性.
- 检查有机体共同培养系统,用于瘤-瘤-免疫交叉研究.
主要方法:
- 对患者衍生器官和基因工程平台的审查.
- 综合瘤微环境共同培养系统的分析.
- 探索新兴技术,如芯片上的有机体和人工智能驱动的分析.
主要成果:
- 器官可以解读致癌,克隆进化和转移.
- 共同培养系统有助于研究瘤-瘤-免疫相互作用.
- 有机生物库在预测个性化治疗反应方面表现有前途.
结论:
- 人类瘤器官是功能精准医学不可或缺的工具.
- 克服微环境建模方面的挑战对于未来的进步至关重要.
- 有机体正在演变为动态的"活生物传感器",用于药物发现和生物标记物识别.
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