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功能与结构的合:大脑重组在老年与认知障碍有关

Xiaojie Li¹, Weilong Fu¹, Yao Wang^1,2

¹School of Life Sciences, Tiangong University, Tianjin 300380, China.

|February 16, 2026

概括

与年龄相关的听力损失 (听力衰弱) 与大脑结构性缩和功能衰退有关,特别是在状回形和门. 降低功能结构比 (FSR) 表明听力损失和认知障碍之间存在关键的神经生物学联系.

科学领域:

神经科学是一个神经科学.
老年学是指老年学的学科.
听力学听力学是指听力学.

背景情况:

长或与年龄相关的听力损失是一种常见的神经退行性疾病.
长症越来越多地与认知障碍有关,但根本的神经生物学机制尚未完全理解.
了解听力损失和认知衰退之间的联系对于早期干预和管理至关重要.

研究的目的:

为了研究神经生物学机制,将长与认知障碍联系起来.
评估大脑结构变化,功能性大脑活动和患有大脑的人的认知功能之间的关系.
引入和验证功能结构比率 (FSR) 作为可能的生物标志物,用于与前相关的认知衰退.

主要方法:

在大脑患者和对照组中评估纯色音度测试值 (PTA),语音识别值 (SRT) 和认知能力 (MoCA,AVLT,TMT-A).
使用磁共振成像 (MRI) 测量低频波动的幅度 (ALFF) 进行功能特征和灰色物质体积 (GMV) 进行结构特征.
通过结合ALFF和GMV来计算功能结构比率 (FSR),以评估功能结构合.

主要成果:

发现了GMV缩和改变ALFF之间的显著相关性,在门,状回环,前,和中部上部前回环在presbycusis组.
这些结构和功能变化与PTA和SRT的增加有关,这表明听力障碍和大脑变化之间存在联系.
状回形,前皮和中部上额回形中减少的FSR与增加的PTA和SRT以及较低的认知分数 (MoCA,AVLT) 和延长的TMT-A性能显著相关.

结论:

长症的特征是听觉和高阶认知大脑区域的结构性缩和功能衰退.
减少FSR是与年龄相关的听力损失和认知障碍之间的关键神经生物学联系.
作为一种新的生物标志物,FSR显示出早期查和动态监测与大脑关联的认知衰退的前景.

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