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在人类研究中,Lactobacillus acidophilus KBL409通过肠道微生物的变化改善了血清中的硫酸

Sung Jae Jang^1,2, SungJun Park^3,4,5, Kiuk Lee⁶

¹Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.

NPJ science of food

|February 16, 2026

概括

在慢性脏病患者中,Lactobacillus acidophilus KBL409显著降低了血清中的氧硫酸水平. 这种益生菌干预调节了肠道微生物群,为改善脏健康提供了潜在的策略.

科学领域:

微生物学微生物学
腎臟病學 (nephrology) 是一種醫學專業.
胃肠病学胃肠病学

背景情况:

慢性病 (CKD) 涉及逐渐下降的功能和尿路毒素的积累.
肠-轴突出了肠道微生物群和CKD进展之间的关键相互作用.
尿素毒素,如氧硫酸 (IS),有助于CKD并发症.

研究的目的:

评估Lactobacillus acidophilus KBL409在降低CKD患者尿液中毒素度方面的疗效.
探索L. acidophilus KBL409对肠道微生物组成的影响及其与尿素毒素的关系.

主要方法:

进行了一项多中心,随机,双盲,安慰剂控制的试验.
参与者每天接受L. acidophilus KBL409 (1x10^10 CFU) 或安慰剂16周.
分析了血清IS水平和肠道微生物组成.

主要成果:

与安慰剂相比,L. acidophilus KBL409组的血清IS度显著降低 (p<0.05).与安慰剂相比,L. acidophilus KBL409组的血清IS度显著降低 (p<0.05).
观察到特定肠道细菌属 (Blautia,Butyricicoccus,Lachnospiraceae UCG-004,Megamonas) 的显著减少.
这些细菌在尿性毒素合成途径中与预测的基因呈现出正相关性.

结论:

在CKD患者中,L. acidophilus KBL409有效降低了血清中的氧硫酸水平.
益生菌调节肠道微生物组成,影响尿素毒素合成.
L. acidophilus KBL409通过肠道微生物群调节来管理脏健康,提供了一个有希望的益生菌方法.

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