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Updated: Feb 18, 2026

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集群和一个形状交换机驱动哺乳动物受体氨酸激酶ROS1的激活

Hengyi Li1,2, Jianan Zhang1,2, Tongqing Li1,2

  • 1Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA.

Nature communications
|February 16, 2026
PubMed
概括

研究人员发现了NELL2如何通过诱导集群和构造变化来激活ROS1 (受体氨酸激酶). 这一发现为针对ROS1驱动癌症的新生物疗法铺平了道路.

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