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在LXRα/SREBP1c信号通路中,GCN5驱动着MASLD的进展,通过LXRα/SREBP1c信号通路介导新的脂质生成

Hai-Tao Xiao1, Peng Song2, Jing Jin1

  • 1State Key Laboratory of Natural Medicines, Department of Pharmacognosy, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.

Nature communications
|February 16, 2026
PubMed
概括

一般控制非抑制蛋白5 (GCN5) 通过促进脂肪合成,驱动代谢功能障碍相关的脂肪性肝病 (MASLD) 的进展. 用CPTH2抑制GCN5显示了对MASLD的治疗潜力.

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