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Updated: Feb 18, 2026

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
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Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Published on: November 22, 2021

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一个基于机器学习的药理动力学预测器 (EGFR-PROPK) 用于针对EGFR的PROTACs

Ran Zhang1, Fenglei Li1,2, Yao Liu3

  • 1Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.

Communications chemistry
|February 16, 2026
PubMed
概括

蛋白质溶解向金马 (PROTACs) 显示出治疗前景,但优化它们的药理动力学 (PK) 是一个挑战. 这项研究开发了一种特定于PROTAC的模型,EGFR-PROPK,提高了对半衰期和清除等关键PK属性的预测准确度.

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