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Updated: Feb 18, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
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在初级ER阳性和HER2阴性乳腺癌中同源的重组缺陷

Helen R Davies1, Daniella Black1, Anders Kvist2

  • 1Department of Genomic Medicine, School of Clinical Medicine & Early Cancer Institute, University of Cambridge, Cambridge, UK.

Communications medicine
|February 16, 2026
PubMed
概括

同源复合缺陷 (HRD) 在雌激素受体阳性,HER2阴性乳腺癌 (ERpHER2n BC) 中比在三阴性乳腺癌中少见. 人力资源发展状况可能会影响治疗决策,特别是在化疗使用方面.

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