一个短效的迷幻干预主要抑郁障碍:一个IIa期随机的安慰剂对照试验
David Erritzoe1, Tommaso Barba2, Tiffanie Benway3
1Imperial College London, London, UK. d.erritzoe@imperial.ac.uk.
Nature medicine
|February 16, 2026
概括
双甲基三胺 (DMT) 是一种迷幻药物,在一项针对主要抑郁症 (MDD) 的临床试验中显著减少了抑郁症状. 这种快速起作用的治疗显示了持续的抗抑郁作用长达三个月,并且被很好地容忍.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 重度抑郁症 (MDD) 是全球残疾的主要原因,许多患者对现有治疗没有反应.
- 双甲基三胺 (DMT) 是一种短效迷幻药,具有作为快速抗抑郁药 (AD) 的潜力,但MDD的临床数据很少.
研究的目的:
- 评估静脉注射DMT在患有中度至重度MDD的成年人中的疗效和安全性.
- 评估DMT作为一种新型抗抑郁药疗法的潜力.
主要方法:
- 一个IIa期,双盲,安慰剂控制,随机化试验,涉及34名患有MDD的参与者.
- 参与者接受了单次21.5毫克静脉注射的DMT或安慰剂,随后接受心理治疗支持.
- 主要结局:2周后蒙哥马利-阿斯伯格抑郁评分表 (MADRS) 的变化;次要结局:反应和缓解率.
主要成果:
- 与安慰剂相比,DMT组在2周后的MADRS得分显著减少 (平均差异 = -7.35,P = 0.023).
- 在开放阶段,抗抑郁药的效果持续了长达3个月,不管接受了一剂或两剂DMT.
- 副作用主要为轻度至中度,包括输液部位疼痛,恶心和短暂的焦虑;没有报告严重的不良事件.
结论:
- 一次静脉注射的DMT剂量,结合心理治疗的支持,迅速显著地减少了MDD患者的抑郁症状.
- 治疗是安全的,耐受性良好,持续有效性可观察到长达三个月.
- 作为一种新型,快速起作用的抗抑郁药,DMT显得有前途.
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