硫微生物饮食,遗传倾向和慢性病风险:一个队列研究
Honghao Yang1,2, Yixiao Zhang3, Zheng Ma1,2
1Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
European journal of clinical nutrition
|February 16, 2026
概括
对硫微生物饮食 (SMD) 的更高坚持与慢性病 (CKD) 的风险增加有关,不论遗传倾向如何. 这种饮食模式会影响不同基因背景的脏健康.
科学领域:
- 营养科学 营养科学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 微生物组研究 微生物组研究
背景情况:
- 硫微生物饮食 (SMD) 与代谢硫化合物的肠道细菌有关.
- 慢性病 (CKD) 是一个重要的全球健康问题,具有复杂的风险因素.
- 了解饮食对CKD的影响对于预防和管理至关重要.
研究的目的:
- 为了评估SMD坚持和CKD风险之间的潜在关联.
- 调查遗传风险是否会改变SMD和CKD之间的关系.
- 量化SMD对CKD发病率在人口层面的影响.
主要方法:
- 利用了来自98,491名参与者多次饮食评估的英国生物库数据.
- 根据食物组摄入量和确定的系数计算SMD得分.
- 评估事件CKD,并为CKD构建多基因风险评分 (PRS).
- 采用考克斯比例危险回归来确定危险比率 (HR) 和人口归因分数 (PAF).
主要成果:
- 在较高的SMD得分和增加的CKD风险之间观察到剂量反应关系.
- 在SMD三位数最高的人群中,CKD风险显著增加 (HR:1.24).
- 在基因风险 (PRS) 和SMD对CKD风险的坚持之间没有发现显著的相互作用.
结论:
- 较高的SMD坚持独立地与患CKD的风险更高有关.
- 这种关联无论个体对CKD的遗传敏感性如何,都会持续存在.
- 需要进一步的研究来证实这些发现,并探索潜在的机制.
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