PFAS和One Health:整合人类,动物和环境的观点
Marília Cristina Oliveira Souza1, Fernando Barbosa2, Jose L Domingo3
1School of Pharmaceutical Sciences of Ribeirão Preto, Department of Biomolecular Sciences, University of São Paulo, Av. do Café s/n, Ribeirao Preto, SP, 14040-903, Brazil.
Archives of toxicology
|February 16, 2026
概括
和多醇基物质 (PFAS) 是持久的,生物积累的化学物质,威胁人类,动物和环境的健康. 一个综合的"健康"方法对于管理所有生态系统和人口中的这些复杂风险至关重要.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 和多基基物质 (PFAS) 是无处不在的,持久的和生物积累的化学物质.
- 它们对降解和全球分散的抵抗性需要全面的风险管理方法.
- PFAS对人类,动物和环境健康构成重大威胁.
研究的目的:
- 审查有关PFAS的当前知识,包括其起源,持久性和分散.
- 综合各种物种对暴露途径和毒理学结果的信息.
- 为解决PFAS风险而倡导一个综合的One Health框架.
主要方法:
- 文献综述综合了关于PFAS的当前科学知识.
- 对环境持久性,全球分散和暴露途径的分析.
- 对毒理学数据的评估和跨物种风险评估.
主要成果:
- PFAS源自人为来源,分布在全球各地.
- 暴露发生在通过饮食,受污染的水和母体转移.
- 融合的毒理学结果包括免疫毒性,生殖功能障碍和跨物种致癌性.
结论:
- 一个健康框架对于管理PFAS相互依存的风险至关重要.
- 需要综合战略,包括环境监测,研究和监管.
- 协调的监管框架和跨部门的合作对于有效的PFAS缓解至关重要.
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