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Updated: Feb 18, 2026

Time-Resolved Fluorescence Anisotropy from Single Molecules for Characterizing Local Flexibility in Biomolecules
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Published on: April 25, 2025

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14-3-3ζ与FOXO3a的DNA结合域相互作用,并通过双动机连接来竞争性地解离DNA

Shota Enomoto1, Tomoya Kuwayama1, Shoichi Nakatsuka1

  • 1Graduate School of Pharmaceutical Sciences, Keio University 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan.

Nature communications
|February 16, 2026
PubMed
概括

14-3-3ζ蛋白与酸化FOXO3a (一种瘤抑制剂) 结合,将其从DNA中移除,从而阻止了亡. 这项研究揭示了14-3-3ζ直接与DNA结合竞争,抑制癌细胞的增殖.

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