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微塑料诱导的皮肤疾病的新兴机制:从肠-皮肤轴的角度来看
Xueer Zhang1,2, Pai Zheng1, Mingxiao Yang1
1Department of Dermatology, Chengdu University of Traditional Chinese Medicine, Chengdu, 6610075, People's Republic of China.
Journal of translational medicine
|February 17, 2026
概括
微塑料 (MPs) 破坏肠道微生物群和皮肤屏障,影响肠-皮肤轴. 准肠道微生物群可能是一种减少MP引起的皮肤损伤的方法.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 免疫学 免疫学 免疫学
背景情况:
- 微塑料 (MP) 是通过多种途径进入人体的普遍污染物.
- 肠-皮肤轴是一个双向通讯通道,连接了胃肠和皮肤系统.
- 众所周知,MPs会破坏肠道微生物群和肠道屏障功能,并损害皮肤健康.
研究的目的:
- 审查微塑料暴露诱导肠道微生物群失调和皮肤损伤的机制.
- 探索肠-皮肤轴在中介微塑料毒性的作用.
- 突出肠道和皮肤健康之间的相互作用在微塑料暴露的背景下.
主要方法:
- 关于研究微塑料对肠道微生物群和皮肤的影响的文献综述.
- 分析微塑料诱导的肠道功能障碍和皮肤屏障损伤的机制.
- 从肠-皮肤轴的角度整合发现.
主要成果:
- 微塑料暴露会导致肠道微生物群的失生,并损害肠道屏障的完整性.
- 微塑料可以损害皮肤屏障功能,导致炎症,代谢失衡和氧化应激.
- 肠道细菌和代谢物的转移到循环中,有助于系统性影响,包括皮肤损伤.
结论:
- 肠-皮肤轴为了解微塑料诱导的毒性提供了一个至关重要的框架.
- 微塑料诱导的肠道功能障碍和屏障功能障碍可以导致或加剧皮肤疾病.
- 调节肠道微生物群可能是减轻微塑料相关皮肤疾病的可行策略.
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