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使用LC-MS/MS检测湿巾中的酸盐化合物:风险评估和LC-QTOF/MS发现

Cagatay Oltulu¹, Saffet Çelik², Mustafa Dasman¹

¹Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Trakya University, Edirne, Turkey.

Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering

|February 17, 2026

概括

在湿巾中检测到甲酸盐,其中一些超出了安全限制和规定. 这凸显了塑化剂带来的风险,以及需要更好的产品安全和标签.

科学领域:

环境化学环境化学
毒理学毒理学毒理学
消费者产品安全产品安全

背景情况:

酸盐是常见的增塑剂,具有内分泌干扰特性.
人们对消费品 (如湿巾) 中的甲酸盐暴露存在担忧.

研究的目的:

在湿巾样本中量化甲酸盐度.
评估与皮肤暴露甲酸盐相关的健康风险.
评估监管合规性和产品安全性.

主要方法:

在使用LC-MS/MS的15个湿巾样本中分析了11个甲酸衍生物.
对非致癌性和致癌性影响的风险评估.
使用LC-QTOF/MS识别未申报的化合物.
检查包装和标签的合规性.

主要成果:

在所有样本中都发现了二甲基甲酸盐 (DEP);在5个样本中检测到其他甲酸盐.
非致癌风险在可接受的范围内;DEHP癌症风险低于值.
确定了未申报的过敏原和刺激物.
对于DEHP和DBP的监管不合规; 6/15个样本没有达到标签要求.

结论:

湿巾可能含有禁止的酸盐和未申报物质,构成潜在的风险.
严格的监管执法和透明的标签对于消费者安全至关重要.
这些发现表明,需要在湿巾制造业改善质量控制.

关键词:

暴露于甲酸盐的情况化品安全的安全性内分泌干扰物干扰内分泌干扰物风险评估风险评估风险评估湿湿的湿巾可以使用.

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