在同一天的模拟无空间分成的适应性放射治疗 (SF-ART) 的体试验.
Dennis N Stanley1, Alyssa R Birchmeier1, Carlos E Cardenas1
1Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Journal of applied clinical medical physics
|February 17, 2026
概括
这项研究表明,新的一天,无模拟放射治疗工作流程是可行的. 空间分成的适应性放射治疗 (SF2 -ART) 可以在没有CT模拟的情况下快速进行,从而保持治疗质量.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
- 计算生物学是一种计算生物学.
背景情况:
- 空间分离放射疗法 (SFRT) 提供剂量升级的好处.
- 适应性放射治疗 (ART) 通过适应解剖变化来提高治疗的准确性.
- 将这些技术整合到精简的工作流中是一项挑战.
研究的目的:
- 评估空间分离适应性放射治疗 (SF-ART) 的同日,无模拟工作流程的可行性和可交付性.
- 评估Varian Ethos平台对于这种新的工作流程的能力.
- 为了确定CT模拟是否可以消除SF-ART.
主要方法:
- 一个in-silico试验涉及10名患者 (5个胸部,5个四肢) 之前接受过SFRT治疗.
- 一个两相模拟方案,包括SBRT和GTV提升.
- 使用定制脚本进行高剂量矩阵和基于CBCT的调整的无模拟规划.
主要成果:
- 所有10个案例都成功地使用SF2-ART工作流程重新规划,没有模拟CT.
- 整个计划和治疗过程在一次会议内完成.
- 与原始计划相比,剂量测量质量保持在最小的差异中;中位数工作流程时间为166.4分钟.
结论:
- 同一天,无模拟的SF2-ART是使用Varian Ethos平台可行的.
- 这种工作流可以为紧急的患者呈现提供快速,高质量的治疗.
- 支持对SF2-ART实施的未来临床试验.
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