开发和验证TOPAS蒙特卡洛模型,用于0.5T双平面Linac-MR
Alireza Gazor1, Michael Reynolds2,3, Andrei Ghila1,4
1Medical Physics Division, Department of Oncology, University of Alberta, Edmonton, Alberta, Canada.
Medical physics
|February 17, 2026
概括
这项研究开发了一个0.5T Linac-MR系统的蒙特卡洛 (MC) 模型,验证了其在磁场中剂量计算的准确性. 该模型精确模拟剂量沉积,确保在MR引导治疗中可靠的放射治疗规划.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 计算机建模 计算建模
背景情况:
- 磁共振 (MR) 导向放射治疗为适应性治疗提供实时成像,但由于磁场对剂量沉积的影响,它存在挑战.
- 在MR导向放射治疗中,精确的剂量计算需要详细的蒙特卡洛 (MC) 建模来考虑磁场影响.
研究的目的:
- 开发和验证一个0.5T双平面Linac-MR系统的综合MC模型.
- 在TOPAS MC模拟平台中集成和验证一个定制设计的多叶合器 (MLC) 模块.
主要方法:
- 在TOPAS中为0.5 T双平面Linac-MR (Aurora-RT) 开发了一个详细的MC模型,具有6 MV FFF光束.
- 整合了3D磁场矢量图和模拟的linac头部部件,包括STL文件中的MLC.
- 通过将模拟剂量分布 (PDD,配置文件,输出因子,MLC传输,表面剂量) 与水箱测量和薄膜剂量计进行比较,验证了该模型.
主要成果:
- 优化的电子源参数 (5.5 MeV 能量,1.3 mm 辐射分布) 在MC模拟和测量之间取得了很好的一致性.
- 模拟剂量分布 (PDD,配置文件) 符合严格的玛标准 (1%/1毫米和2%/2毫米) 与不同场面大小的测量相比.
- 验证了MLC传输和定位精度,模拟的表面剂量与实验数据密切匹配.
结论:
- 开发的TOPAS MC模型准确地模拟了0.5 T Linac-MR中的剂量沉积,为剂量验证提供了可靠的工具.
- 集成的MLC模块及其定位机制已被验证用于开放光圈应用,增强处理规划能力.
- 这种经过验证的MC模型作为一个强大的框架,用于在磁场存在时精确的剂量模拟.
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