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核医学在预测肝细胞癌反应中的作用

Haibin Tu¹, Dingluan Lin², Xiaoxiong Wu³

¹Department of Ultrasound.

Nuclear medicine communications

|February 17, 2026

概括

核医学成像,包括PET/CT和SPECT,为预测肝细胞癌 (HCC) 治疗反应提供了非侵入性生物标志物. 这些先进技术有助于早期适应免疫疗法和向疗法,以获得更好的患者结果.

科学领域:

核医学是一种核医学.
在瘤学瘤学.
放射学放射学是指放射学

背景情况:

尽管在免疫检查点抑制剂和抗血管原性疗法方面取得了进展,但肝细胞癌 (HCC) 治疗结果的差异很大.
非侵入性生物标志物对于HCC管理中的早期治疗适应至关重要.

研究的目的:

审查核医学方法的临床和转化证据,以预测HCC的治疗反应和预后.
探索PET/CT,SPECT,放射学,机器学习和神经学在免疫疗法和向药物治疗的HCC中的作用.

主要方法:

对HCC核医学技术的临床和翻译研究的审查.
对代谢性PET/CT,免疫向性PET/SPECT,基于PET的放射学,机器学习和发光学进行分析.
评估体积指数 (例如代谢性瘤体积) 和免疫表型的成像替代品.

主要成果:

代谢性PET/CT,特别是使用18F-氧糖,有助于风险分层,其体积指数如代谢性瘤体积 (MTV) 显示出预后价值.
免疫向PET/SPECT可以绘制目标可用性和免疫激活的地图,尽管研究通常很小,而且是回顾性的.
基于PET的放射学和机器学习显示了成像免疫表型的潜力,但面临着可重现性挑战.

结论:

核医学为HCC的反应预测和预后提供了有前途的非侵入性生物标志物.
需要进一步的研究,包括多中心验证和协调协议,以实现这些先进的成像技术的常规临床转化.

关键词:

在这里,PET是PET.肝细胞癌是肝细胞癌.免疫疗法免疫疗法无线电学 (radiomics) 是一种无线电学.单光子发射计算机断层扫描.

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