尼古丁酸修饰的奇托桑纳米颗粒用于增强复星的输送和抗癌活性
Sema Şentürk1,2, Özlem Kaplan3, Kevser Bal2
1Department of Chemical Engineering, Istanbul Health and Technology University, Faculty of Engineering and Natural Sciences, Istanbul, Türkiye.
Biopolymers
|February 17, 2026
概括
这项研究开发了与尼古丁酸 (ChiNico) 功能化的新奇奇纳米颗粒,用于增强药物输送. 这些装有白醇 (nChiNico-RES) 的纳米颗粒显示出对癌细胞的抗癌活性得到改善,同时不影响健康细胞.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 奇托是一种生物相容的聚合物,在生理pH下具有有限的溶解性和缓冲能力.
- 尼古丁酸 (维生素B3) 具有生物活性,并可能增强基托桑的特性.
- 开发用于癌症治疗的有效药物输送系统仍然是一个关键的挑战.
研究的目的:
- 用尼古丁酸使奇托功能化,制造出具有改善物理化学性质的衍生品 (ChiNico).
- 开发含有白醇的ChiNico纳米粒子 (nChiNico-RES),以提高抗癌效果.
- 评估开发的纳米颗粒的体外抗癌活性和生物相容性.
主要方法:
- 通过EDC介导的化,用尼古丁酸对奇托桑进行功能化.
- 使用FTIR,1H NMR和GPC/SEC.的衍生品的表征.
- 纳米颗粒通过离子热凝的制备和尺寸,PDI和表面电荷的表征.
- 在实验室中对HeLa,HT-29癌细胞系和BJ纤维细胞进行细胞毒性测定.
主要成果:
- 通过光谱和尺寸排除色谱分析证实了ChiNico的成功合成.
- 奇尼科在生理pH下表现出增强的溶解性和改善的质子缓冲能力.
- 载有复星的纳米粒子 (nChiNico-RES) 显示出最佳尺寸 (100-140nm),PDI (<0.4) 和正面电荷 (+18到+20mV).
- 在体外,nChiNico-RES对HeLa和HT-29细胞的抗癌活性优于自由复星和未修改的基托桑纳米颗粒,对BJ纤维细胞的毒性最小.
结论:
- 尼古丁酸功能化显著增强了奇托桑用于纳米颗粒配方的特性.
- 开发的nChiNico-RES系统为向癌症治疗提供了一个有前途的平台,利用了奇托,尼古丁酸和白醇的综合益处.
- 这种方法代表了从自然生物活性分子中创建多功能纳米粒子的新策略.
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