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Updated: Feb 18, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

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一个务实的PBPK驱动的战略,以指导ADME的特征和早期人类PK预测ECCS类1B/3B化合物

David Cebrián1, Line Oste2, Dries Van den Bossche2

  • 1Integrated Drug Discovery, Selvita SA, Podole 79, Kraków 30-394, Poland.

Journal of medicinal chemistry
|February 17, 2026
PubMed
概括

一个新的分层生理学基础药理动力学 (PBPK) 框架有助于早期药物发现. 这种方法简化了对zwitterions和酸的预测人类药理动力学 (PK),减少了实验需求.

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Pharmacokinetic-pharmacodynamic (PK–PD) modeling is essential in drug development and clinical pharmacology. It provides a quantitative framework to predict drug behavior and response over time. This approach integrates pharmacokinetics (PK), which describes the drug's absorption, distribution, metabolism, and excretion, with pharmacodynamics (PD), which characterizes the drug’s biological effects and mechanisms of action.The disposition kinetics of a drug determine its plasma...
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