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Updated: May 13, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
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基于FGF2的循环PET追踪器用于非小细胞肺癌中非侵入性检测FGFR1表达的非侵入性检测

Yan Xue1,2, Zhihong Huang1,2, Xue Zhu1,2

  • 1National Health Commission Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, China.

Journal of medicinal chemistry
|February 17, 2026
PubMed
概括

一种新型的循环放射追踪剂Ga-NOTA-cRY9M显示出在非小细胞肺癌 (NSCLC) 中检测FGFR1过度表达的前景. 这种药物可以改善瘤向性和稳定性,用于NSCLC患者的潜在诊断应用.

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Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical, 7TM, or...