可转移的元素作为Drosophila virilis中的基因组进化的驱动因素
Alexander P Rezvykh1, Dina A Kulikova2, Elena S Zelentsova1
1Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow 119991, Russia.
Nucleic acids research
|February 17, 2026
概括
可转移元素 (TE) 推动了Drosophila virilis.中的基因组创新. 这些移动遗传元素表现出动态活动,水平转移,并影响基因调节和进化.
科学领域:
- 基因组学就是基因组学.
- 进化生物学 进化生物学
- 分子生物学分子生物学
背景情况:
- 可转移元素 (TE) 是基因组创新的关键驱动力,但它们在非模型生物中的动力学知之甚少.
- 草虫是一种有价值的模型系统,用于研究重复性DNA和可转移元素.
研究的目的:
- 通过使用集成的多omics数据,研究Drosophila virilis中可转移元素的动态.
- 了解TEs对基因组进化,基因调节和D. virilis的物种化的影响.
主要方法:
- 整合多omics数据 (基因组,表观基因组).
- 可转换元素家族的计算预测和手动策划.
- 表观遗传特征 (H3K9me3) 和分析TE插入部位及其对基因表达的影响.
主要成果:
- 确定了100个可转移的元素家族,有三个不同的动员波:最近的,与物种相关的和古老的.
- 证明了euchromatin和heterochromatin的动态TE殖民,其中一些TE显示了菌株特定的活动.
- 提供了在D. virilis物种群内水平转移TE的证据,形成了TE"生态系统".
- 显示了从TEs传播的H3K9me3以距离依赖的方式抑制邻近的基因,影响基因调节.
- 发现了第一个与逆转移子相关的D. virilis的自发多态逆转.
结论:
- 可转移的元素是基因组创新和Drosophila virilis的进化轨迹的重要驱动因素.
- 通过表观遗传机制,TEs积极影响基因调节,并对基因组结构变异作出贡献.
- 该研究为了解TE动态及其对各种动物物种基因组进化影响提供了一个框架.
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