在乳腺炎的体外模型中,牛分泌过物的保护作用
Gianluca Antonio Franco1, Ylenia Marino2, Rosalia Crupi1
1Department of Veterinary Science University of Messina Messina Italy.
Veterinary record open
|February 17, 2026
概括
牛分泌过物有效地减少了牛乳腺炎模型中的炎症和氧化应激. 这种天然疗法显示出可持续疗法的前景,与"一个健康"的方法保持一致.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
背景情况:
- 牛乳腺炎带来经济挑战,并导致抗生素耐药性.
- 越来越多地寻求可持续的治疗替代方案来管理这种情况.
研究的目的:
- 为了评估牛分泌液 (SSF) 的抗炎和抗氧化特性,来自*Helix Aspersa Muller*.
- 在牛乳腺炎的体外模型中评估SSF的疗效.
主要方法:
- 牛乳腺细胞 (MAC-T) 用脂多糖 (LPS) 刺激,诱导炎症.
- 用SSF对细胞进行治疗,以分析对氧化应激,炎症性细胞因子 (TNF-α,IL-6,IL-1β) 和关键炎症酶 (iNOS,COX-2) 的影响.
- 通过测量血氧酶1 (HO-1) 表达的方法来评估细胞保护作用.
主要成果:
- 由LPS引起的SSF显著降低了活性氧物种和促炎性细胞因子的产生.
- SSF调节了iNOS和COX-2的表达,降低了它们的水平.
- 增加的HO-1表达表明SSF的细胞保护作用.
结论:
- 牛分泌过物在减轻牛乳腺炎的炎症和氧化应激方面表现出有效性.
- 作为一种天然和可持续的治疗剂,SSF具有潜力.
- 调查结果支持将SSF纳入动物健康的One Health框架.
相关概念视频
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