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Updated: Feb 18, 2026

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双对应的染色体和一个潜在的声器,用于人类丸中PRSS基因的差异表达

Kouta Iijima¹, Ryuzaburo Shibayama², Chika Fujimori^1,2,3

¹Graduate School of Life Science, Hokkaido University, Sapporo, Japan.

Molecular reproduction and development

|February 17, 2026

概括

人类PRSS基因调节与小鼠不同,在精子发育过程中双价色染色素和沉声器控制表达. 这揭示了人类精子生成基因控制的关键机制.

科学领域:

生殖生物学生殖生物学
遗传学是一个遗传学.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

精子发生过程中的基因调节在模型动物中被理解,但不是人类.
小鼠Prss/Tessp locus为丸特定基因调节提供了一个模型.

研究的目的:

研究灵长类动物,特别是人类中PRSS位点的表达和调节.
将人类和小鼠之间的PRSS基因调节进行比较.

主要方法:

分析了包括人类在内的六种灵长类动物的PRSS基因表达.
在人类生殖细胞中利用了ChIP-seq (基因素修饰H3K4me3和H3K27me3).
执行ATAC-seq以识别监管元素和测试声器活动.

主要成果:

与小鼠不同,灵长类动物仅表现出一个或两个PRSS基因的占主导性表达,在人类中PRSS50占主导性.
在人类中,低表达的PRSS基因表现出双价染色素 (H3K4me3和H3K27me3),与它们的小鼠正义基因 (仅H3K4me3) 不一样.
一个ATAC-seq识别的峰值显示了PRSS45的沉默器活性,这是一种在人类表达较低但在黑猩猩表达较高的基因.

结论:

双对应色素和活性沉声器合作,在人类精子生成过程中调节PRSS基因表达.
这些发现为人类精子生成基因调节提供了机理性的见解,与模型生物不同.

关键词:

双价色色素的双价色色素是一种双价色色素.人类PRSS的位置记者基因检测分析沉声器是一种沉声器.精子的产生是精子的产生.

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