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微型/纳米塑料诱导甲状腺毛囊细胞烧灭,通过激活NF-κB信号传递来触发甲状腺毒性

Fangda Fu¹, Yuying Chen^1,2, Huan Luo³

¹Institute of Orthopaedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, PR China.

Annals of medicine

|February 17, 2026

概括

微塑料和纳米塑料通过触发细胞死亡和炎症而导致甲状腺损伤. 纳米塑料显示出更强的效果,其机制涉及热致死和NF-κB信号传递.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
内分泌学在内分泌学.

背景情况:

微塑料和纳米塑料 (MNP) 是广泛存在的环境污染物.
多核可以生物累积,并对健康构成风险.
接触MNP会影响多个器官系统,但甲状腺毒性机制尚不清楚.

研究的目的:

调查MNP诱导的甲状腺毒性的机制.
评估微塑料 (MP) 和纳米塑料 (NP) 对甲状腺功能和结构的影响.
阐明 pyroptosis 和 NF-κB 信号在 MNP 甲状腺毒性中的作用.

主要方法:

在4周和8周内,小鼠通过胃内测量暴露于MP (5μm) 或NP (50nm).
评估了甲状腺结构和激素水平.
分析了亡,炎症,亡标志物和NF-κB信号传递.

主要成果:

接触MNP会破坏甲状腺结构和内分泌功能.
甲状腺表现出增加的亡和炎症性细胞因子产生,NP具有更大的影响.
通过NF-κB通路激活,MNP暴露在甲状腺毛囊细胞中诱导了 pyroptosis.

结论:

暴露于MNP会导致显著的甲状腺毒性.
由NF-κB信号驱动的毛细胞灭是MNP诱导的甲状腺损伤的关键机制.
这些发现提高了对塑料污染对健康的影响的理解.

关键词:

微型/纳米塑料是一种塑料.通过NF-κB信号通路传递信号.在NLRP3炎症酶组中,热致灭 (pyroptosis) 是一种致的过程.甲状腺毒性甲状腺毒性

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