在心房的患者中,嗅觉功能障碍和系统性免疫炎症指数增加
Ercan Akşit1, Ahmet Köder2, Uğur Özkan3
1Department of Cardiology, Canakkale Onsekiz Mart University Faculty of Medicine, Canakkale, Türkiye.
Biomolecules & biomedicine
|February 17, 2026
概括
患有心房 (AF) 的患者表现出嗅觉功能受损和炎症增加. 嗅觉测试和炎症标志物可以帮助评估AF症状的严重程度.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 心房动 (AF) 是一种常见的心律失常,与严重的健康问题有关.
- 嗅觉功能障碍和慢性炎症可能共享潜在的血管和神经炎症机制.
- 需要可访问的标记物来量化AF疾病负担.
研究的目的:
- 评估被诊断为心房动 (AF) 的患者的嗅觉功能.
- 研究通过全身免疫炎症指数 (SII) 测量的全身炎症与AF之间的关联.
- 探索嗅觉功能,炎症和AF症状严重程度之间的关系.
主要方法:
- 一项涉及85名成年人 (43名有AF,42名对照) 的病例控制研究.
- 嗅觉功能使用Sniffin' Sticks扩展测试 (气味值,歧视,识别,TDI得分) 进行评估.
- 系统性免疫炎症指数 (SII) 是从全血细胞计数计算出来的.
主要成果:
- 与对照组相比,AF患者的SII显著增加 (p = 0.007).
- AF患者的嗅觉功能较差,嗅觉值,辨别,识别和TDI得分较低 (所有患者p < 0.001).
- 在AF组中,降低的嗅觉性能和TDI得分与增加的症状严重程度 (EHRA分类) 和更高的SII相关.
结论:
- 心房动与嗅觉功能受损和系统性炎症升高有关.
- 嗅觉功能和SII等炎症指数可能作为AF症状负担的潜在相关物.
- 需要在更大规模的前性研究中进行进一步的验证,并进行持续的节律监测.
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