区域查时代的输血传染婴儿病:哪些病例仍在出现?
Rebecca Townsend1, Paul Losco2, Laura Tonnetti1
1American Red Cross Biomedical Services, Medical and Scientific Office, Washington, District of Columbia, USA.
Transfusion
|February 17, 2026
概括
区域贝贝西亚查显著降低了输血传播的贝贝西亚病 (TTB) 的风险. 然而,捐献者前往非流行状态的旅行构成了持续的威胁,需要对当前的献血查策略进行持续监测.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 输血医学 输血医学
背景情况:
- 美国食品和药物管理局 (FDA) 要求从2020年5月开始,在19个高风险州和华盛顿特区进行贝贝西亚查,以减轻输血传播的贝贝西亚病 (TTB).
- 查涉及转录介导放大 (TMA) 核酸测试 (NAT) 在汇集的血液样本,与反应性样本进一步通过免疫光检测 (IFA) 测试Babesia microti抗体.
研究的目的:
- 评估区域Babesia献血查战略的有效性.
- 确定TTB预防的剩余风险和脆弱性,特别是与捐赠者旅行相关的风险和脆弱性.
主要方法:
- 分析Babesia查数据和TTB病例报告,由美国红十字会 (ARC) 从2021年10月到2025年12月确定.
- 调查涉及的捐赠,捐赠者的旅行史和收集的地理来源.
主要成果:
- 确定了四例TTB病例,所有病例都与在非流行国家收集的捐赠有关.
- 在所有确定的病例中,捐赠者曾前往或居住在巴贝西亚流行地区,这突显了捐赠者流动性的影响.
结论:
- 目前的区域巴贝西亚查方法已大大降低了TTB风险.
- 捐赠者旅行仍然是TTB传播的重要因素,强调需要持续监测和潜在的地理查政策的完善.
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