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在当地种群中,多年来发生的突变差异是自线虫Caenorhabditis elegans的本地种群

Xu Wei^1,2, Aurélien Richaud¹, Robyn E Tanny³

¹Institut de Biologie de l'École Normale Supérieure, Centre National de la Recherche Scientifique, 46 rue d'Ulm, 75005 Paris, France.

|February 17, 2026

概括

这项研究追踪了13年来自然Caenorhabditis elegans种群中的突变. 我们估计每年每个基因对的突变率为4-5x10^-8,并观察到有限的分散,揭示了时空模式.

科学领域:

进化生物学进化生物学
人口遗传学人口遗传学
基因组学就是基因组学.

背景情况:

突变积累实验通常发生在受控的实验室环境中.
自然种群提供了真实世界条件下的突变动态的见解.
一种自我繁殖的线虫Caenorhabditis elegans非常适合在现场研究突变积累.

研究的目的:

调查C. elegans天然种群中自发突变的积累和命运.
在空间和时间背景下分析突变模式.
估计自然C. elegans种群中的替代率和有效生成时间.

主要方法:

在13年 (2009-2022) 收集的C. elegans个体的全基因组测序.
沿着300米长的溪岸对克隆基因型的分析,以追踪突变积累.
遗传学分析以检测时间信号和估计突变率.

主要成果:

估计每基因对的替代率为每年4-5x10^-8个突变.
在X染色体,染色体臂和非异构区域观察到更高的突变密度.
检测到一个高的转换转换比率,与实验室发现不同.
在当地C. elegans种群中每年推导大约25个有效世代.
确定了空间时间模式,表明分散有限 (在10年内<100米).

结论:

自然种群提供了关于突变速率和模式的宝贵数据.
估计的突变率可以校准进化研究中的分歧时间.
在自然环境和实验室环境中,C. elegans表现出明显的突变特征.
有限的分散影响了自然种群中突变的空间分布.

关键词:

这里是C. elegans.这是WormBase的基础.生命周期生命周期突变率的变化率是如何发生的突变偏差是一种突变偏差.自然种群的自然种群.多态的多态化.

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