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整合多级FE2M模拟和实验,预测软骨中的微裂纹损伤

Kosar Safari¹, Ashkan Almasi¹, Phoebe Szarek¹

¹School of Mechanical, Aerospace, and Manufacturing Engineering, University of Connecticut, Storrs, CT, United States.

Journal of biomechanical engineering

|February 17, 2026

概括

关节软骨微损伤是骨关节炎 (OA) 的前体,可以使用多尺度计算模型进行预测. 该框架准确地捕捉了撞击和周期性负载下的原体网络故障,有助于OA研究.

科学领域:

生物医学工程生物医学工程
计算力学计算力学计算力学
组织工程是组织工程.

背景情况:

关节软骨容易受到撞击的微伤害,可能导致关节性关节炎 (OA).
了解原蛋白网络机制对于预测软骨衰竭至关重要.
现有的模型往往缺乏用于准确损害预测的多尺度集成.

研究的目的:

开发和验证一个多尺度计算框架 (FE2M),用于预测关节软骨中微伤害的发起和传播.
为了将宏观软骨变形与微观纤维机制结合起来.
为了研究压力与拉伸在软骨衰竭中的作用.

主要方法:

在FEBio中使用了多尺度混合物的有限元素 (FE2M) 框架.
生成统计等价的代表体积元素 (SERVEs) 来建模异型原体结构.
模拟撞击和循环压缩负载条件,根据实验数据进行验证.

主要成果:

纤维故障分数的FE2M预测与实验测量的微裂纹分数强烈一致.
高冲击模拟显示压力,而不是拉伸,作为更可靠的失败预测器.
模型证明了纤维纤维硬度参数变化的稳定性.

结论:

经过验证的FE2M框架准确地捕捉了关节软骨中的多尺度机械行为和微损伤趋势.
这种方法为了解软骨退化提供了一个预测工具.
潜在的应用包括伤害风险评估和OA预防策略.

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