达里多雷克桑的临床毒性:毒药中心数据中心的回顾性分析
Katharina von Fabeck1, Jean-Paul Boudsocq2, Matthieu Boye2
1Institut de Neurosciences de la Timone, UMR7289 CNRS, Hop Sainte Marguerite, Department of Clinical Pharmacology, CAP-TV, Aix Marseille Univ, APHM, Marseille, France.
Clinical toxicology (Philadelphia, Pa.)
|February 17, 2026
概括
达里多雷克桑特过量用药的病例严重程度较低,没有死亡. 与其他物质同时摄入,特别是在女性中,增加了毒性风险,强调了在多药学中需要谨慎.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 临床医学 临床医学
背景情况:
- 达里多雷克桑 (Daridorexant) 是一种用于治疗失眠的双素受体对抗剂.
- 关于达里多雷克桑特急性毒性和过量服用的现实数据有限.
- 了解过量使用的特征对于患者的安全至关重要.
研究的目的:
- 为了描述临床表现,严重程度和达里多雷克桑特暴露的结果.
- 为了调查同时摄入物质在过量严重性中的作用.
- 为了确定达里多雷克桑毒性的潜在的性别特异性差异.
主要方法:
- 对向法国毒药中心网络报告的达里多雷克桑特暴露病例的回顾性审查 (2024年3月 - 2025年5月).
- 数据提取包括人口统计,临床和毒理信息.
- 毒害严重程度得分 (PSS) 用于评分严重程度;后勤回归分析了共毒效应.
主要成果:
- 分析了51例病例,其中70.6%为女性.
- 单一中毒主要导致昏昏欲睡;同时中毒涉及中枢神经系统抑郁剂,导致诸如昏迷等严重症状.
- 同时中毒与女性的重症增加有显著的关联 (P=0.0086).
结论:
- 当单独服用Daridorexant过量服用时,其严重程度通常较低.
- 同时摄入会显著增加毒性,特别是在女性身上.
- 在涉及达里多雷克桑和中枢神经系统抑制剂的多药房病例中建议采取临床警.
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