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通过协同超声波和氧化物诱导的能量转移进行空间时间控制的NIR-II光后纳米探针,用于精确的超声波

Jimei Wang¹, Hanxun Zou², Jining Qin¹

¹State Key Laboratory of Chemical Resource Engineering, College of Chemistry, College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029, China.

Journal of the American Chemical Society

|February 17, 2026

概括

研究人员开发了一种新的近红外II (NIR-II) 后发光纳米探针,用于精确的瘤成像和治疗. 这种双刺激响应式探针使用超声波和瘤特异性过氧酸盐来实现时空控制,以加强癌症诊断和治疗.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
医疗成像医学成像
热浪学是什么意思热浪学

背景情况:

空间时间控制的光后发光探针对于非侵入性疾病诊断和治疗至关重要.
开发具有高成像特异性和治疗功效的长波长余发光探针仍然具有挑战性.

研究的目的:

介绍一种新的时空控制的近红外II (NIR-II) 后发光纳米探针 (FZ970) 用于精确的瘤成像和治疗.
为了利用一个协同的双刺激机制,涉及超声波和瘤特异性过氧酸 (ONOO-),用于控制后照辐射.

主要方法:

在一个纳米粒子内对NIR-II光照后基质和声敏剂的联合封装.
远程超声波照射以产生单点氧 (1O2).
瘤特异性过氧酸盐 (ONOO-) 与单点氧相互作用,通过化学发光共振能量转移 (CRET) 触发化学激发和NIR-II后照.

主要成果:

实现了精确的时空控制后照辐射,使得高瘤选择性和深层组织透.
在成像中展示了最小的背景干扰.
增强的单点氧生产促进了有效的声动力疗法 (SDT) 进行瘤切除和实时监测治疗疗效.

结论:

开发的FZ970纳米探针为精确的癌症治疗学提供了一个有前途的方法.
这项技术通过提高成像准确性和治疗监测,推进了个性化癌症治疗.

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