护理专业人员的职业基因毒性:系统性审查
Thiago Guedes Pinto1, Gabriel Carvalhal de Aguiar1, Lorrany da Silva Avanci1
1Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil.
概括
护理专业人员面临职业接触危险化学品,导致基因毒性影响. 本次审查强调了需要改善监测和保护措施,以防止护士的长期遗传损伤.
科学领域:
- 职业健康 职业健康 职业健康
- 遗传学 遗传学 是一个
- 毒理学 毒理学 毒理学
背景情况:
- 在医疗保健机构,护士专业人员经常接触危险化学物质,如消毒剂,麻醉气体和细胞毒药物.
- 这种暴露引起了对潜在的基因毒性影响和长期健康风险的重大担忧.
研究的目的:
- 系统地审查和调查与护理人员常见的职业暴露相关的基因毒性.
- 综合证据DNA损伤生物标志物在工作场所化学品暴露的护理专业人员.
主要方法:
- 在2025年8月,在主要数据库 (PubMed,SCOPUS,Web of Science) 进行了系统的文献搜索.
- 包括的研究 (n=16) 使用微核试验,彗星试验和人类或哺乳动物细胞染色体异常试验等生物标志物评估了DNA损伤.
主要成果:
- 所有16项研究均一致报告了与护理人员职业暴露相关的基因毒性影响.
- 观察到的效应包括微核的频率增加,DNA链断裂和染色体变化.
- 质量评估显示,16项研究中的15项研究具有中度至强度的方法严格性.
结论:
- 这些发现证实了由于职业化学物质暴露,护理专业人员存在重大基因毒性风险.
- 加强监测和保护策略对于减轻该种群的长期遗传损害至关重要.
- 微核测定被确定为适合用于生物监测护理专业人员的生物标志物.
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