澄清骨质疏松症患者的临床治疗原始状态
David L Kendler1, Jeffrey Habert2, Aliya A Khan3
1Department of Medicine, University of British Columbia, 150-943 West Broadway, Vancouver, BC, V5Z 4E1, Canada. davidkendler@gmail.com.
概括
患有短暂或远程骨质疏松症治疗史的患者可能被认为是临床治疗的无知者. 需要一个统一的定义,以确保高风险个体能够适当地获得骨强化疗法.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 药理学 药理学是指药理学的学科.
背景情况:
- 骨质疏松症治疗对骨矿物质密度和营业额的影响随着时间的推移而消失.
- 患有远程或短暂之前接触骨质疏松症治疗的患者并不严格地说是"治疗天真",但可能会受益于被归类为这样的.
- 在定义"临床治疗天真"方面缺乏明确性,可能会阻碍高骨折风险患者获得关键骨建设疗法.
研究的目的:
- 总结在关键试验和北美骨质疏松症治疗实践指南中使用的"临床治疗天真"的定义.
- 建议在高至非常高骨折风险的患者中为初始治疗提出一致的定义.
- 解决需要明确分类的需求,以防止某些患者群体的潜在劣势.
主要方法:
- 对已批准的骨质疏松症治疗的关键试验中使用的定义的审查.
- 对北美近期实践指南的分析.
- 讨论双酸盐具有独特的骨结合特性和非双酸盐疗法的分离时间.
主要成果:
- 根据各种骨质疏松症药物 (口服双酸盐,静脉双酸盐,德诺苏马布,阿巴洛帕拉提德,罗莫苏马布,特里帕拉提德) 的先前暴露时间和停止时间,对"临床治疗天真"的拟议定义.
- 双酸盐在停止治疗后表现出持续的,尽管有限的,抗吸收活性.
- 非双酸盐疗法相对较快地解决,需要及时过渡以保持疗效.
结论:
- 对于"临床治疗天真"的统一定义对于一致的患者分类至关重要.
- 这一统一的定义将有助于多学科的护理团队和医疗保健决策者在治疗顺序.
- 清晰的定义确保了先前短暂或远程接触骨质疏松症治疗的患者获得适当的治疗方法.
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