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Updated: Feb 19, 2026

NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode
09:19

NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode

Published on: June 4, 2021

3.9K

为Fab甲基组的NMR分配提供了一个快速有效的策略

Faustine Henot1,2, Béatrice Vibert3,4, Arthur Giraud3,4,5

  • 1Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), 71, Avenue des Martyrs, Grenoble, 38044, France. faustine.henot@sanofi.com.

Journal of biomolecular NMR
|February 17, 2026
PubMed
概括

我们开发了一种新方法,使用二维甲基NMR快速分配单克隆抗体 (mAb) 抗原结合片段 (Fabs) 中的甲基组. 这种技术有助于表征治疗性Fabs,这对于药物开发至关重要.

关键词:
没有细胞的细胞.在 IgG1 Fab 中.同位素标签的标签甲基组是甲基组的组成部分.核磁共振 (NMR) 的分配方式

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