早期逆境之间的预测关系,下丘脑-垂体-上腺轴的非线性轨迹的功能,以及后来的冷酷无情的特征
Nicole Huth1, Sarah C Vogel2, Veronica Cole3
1Department of Psychological and Brain Sciences, Boston University, 64 Cummington Mall, Boston, MA, 02215, USA.
Child psychiatry and human development
|February 17, 2026
概括
儿童早期的逆境和特定的压力激素模式与冷酷无情 (CU) 特征有关. 一个具有波动皮质醇水平的独特组显示出更高的CU特征,特别是在早期逆境后.
科学领域:
- 发展心理学是发展心理学.
- 儿童精神病学 儿童精神病学
- 压力生理学 压力生理学
背景情况:
- 粗心无情 (CU) 特性具有复杂的发育起源.
- 早期的社会经验和压力系统的功能,如下丘脑-垂体-上腺 (HPA) 轴,都与此有关.
- 早期逆境,HPA轴功能和后来的CU特征之间的相互作用需要进一步研究.
研究的目的:
- 检查幼儿时代唾液基础皮质醇轨迹,早期逆境和青春期前的CU特征之间的关系.
- 根据皮质醇模式和早期生活压力来确定CU特征的独特发展途径.
主要方法:
- 这是一项长度研究,共有1292名参与者.
- 隐性基础增长混合模型用于分析皮质醇数据.
- 唾液基础皮质醇测量在6,15,24和48个月;逆境评估在6个月;CU特征评估在青春期前 (平均年龄13.22岁).
主要成果:
- 确定了两种皮质醇轨迹类:一种低稳定类 (约. 95%) 和一个不稳定的类从高转为低皮质醇 (约. 5%) 的比例.
- 不稳定的皮质醇类在青春期前表现出明显更高的CU特征,而不是低稳定的类.
- 6个月的早期逆境预测了更高的CU特征,特别是在不稳定的皮质醇类中.
结论:
- 一个特定的生理模式,以不稳定的基底皮质醇为特征,与CU特征的风险增加有关.
- 在这个特定的生理风险组内,早期的逆境在CU特征的发展中起着重要作用.
- 研究结果强调了考虑压力生理学和早期生活经验的重要性,以了解CU特征的异质发育途径.
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