已修改的基本脆弱性工具集用于跨导管中位膜和三膜修复中的风险分层
Matthieu Schäfer1, Clemens Metze2, Caroline F Hasse2
1University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic III for Internal Medicine, Cologne, Germany. matthieu.schaefer@uk-koeln.de.
概括
基本脆弱性工具集 (EFT) 有效预测跨导管中门和三门修复 (TMTVR) 患者的死亡风险. 结合EFT和多维预后指数 (MPI) 的逐步方法进一步完善风险分层,以便做出更好的治疗决策.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 医疗保健服务研究 医疗服务研究
背景情况:
- 建议对跨导管中和三门修复 (TMTVR) 候选人的风险分层进行脆弱性评估.
- 这种患者群体的最佳脆弱性得分仍然未确定.
研究的目的:
- 在接受TMTVR的患者中评估修改的基本脆弱工具集 (EFT) 的预后价值.
- 探索将EFT和多维预测指数 (MPI) 结合起来的一种逐步方法的实用性,以提高风险分层.
主要方法:
- 对206名TMTVR患者的回顾性分析.
- 基于步行速度,认知障碍,血红蛋白和血清白蛋白的修改基本脆弱性工具集 (EFT) 的计算.
- 考克斯的比例危险模型来评估EFT脆弱性和所有原因死亡率之间的关联.
主要成果:
- EFT证明了预后价值,预先脆弱和脆弱患者的死亡风险增加.
- 使用EFT和MPI的逐步方法确定了两种风险类别,两年死亡率的差异是4.4倍.
- 在调整其他风险因素后,EFT和死亡率之间的关联仍然存在,但MPI减弱了它.
结论:
- 基本脆弱性工具集 (EFT) 是一个有价值和简单的工具,用于初步评估TMTVR候选人的脆弱性.
- 在先前脆弱的患者中,EFT的逐步应用,其次是MPI可以显著改善风险分层.
- 这种方法有助于TMTVR程序的治疗决策.
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