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第三手电子烟暴露的原血栓现象是独立于性别的,并且涉及对血小板功能的全身中介作用:来自小鼠模型的证据

Shelby S Umphres¹, Ahmed B Alarabi¹, Hamdy E A Ali¹

¹Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, 1010 W Avenue B, Kingsville, TX, 78363, USA.

Cardiovascular toxicology

|February 17, 2026

概括

第三手电子烟暴露 (THEC) 在雄性和雌性小鼠中引起过度活跃的血小板和前血栓状态. 这种心血管风险与系统性炎症和THEC改变的细胞因子概况有关.

科学领域:

心血管科学心血管科学
毒理学毒理学毒理学
血液学血液学血液学

背景情况:

电子烟 (e-cigs) 有助于与心血管疾病 (CVD) 相关的炎症反应.
第三方暴露于电子烟毒素 (THEC) 涉及沉降的,化学变化的残留物,构成潜在的健康风险.
THEC被认为是一种新的暴露途径,对全身健康有影响.

研究的目的:

研究THEC对小鼠血小板活性和全身炎症的影响.
为了确定THEC暴露反应的性别特异性差异.
阐明THEC诱导的血小板过敏反应和心血管风险背后的机制.

主要方法:

在四个月的时间里,小鼠暴露在THEC中.
通过出血时间,遮时间,聚合和颗粒分泌来评估血小板反应性.
在血中分析了细胞因子概况,并使用THEC暴露的血在体外测试了血小板功能.

主要成果:

THEC暴露导致了双性多异的高活性血小板表型 (缩短出血/遮时间,增强聚合/分泌).
血小板过敏反应是由THEC暴露的血中的全身因素调解的,独立于直接的血小板暴露.
在THEC暴露的小鼠中观察到细胞因子配置的性别依赖性失调.

结论:

暴露于THEC会在小鼠中诱导原血栓现象型,对雄性和雌性都有类似的风险.
血栓前作用部分通过通过改变的细胞因子概况对血小板反应性的间接系统作用来调节.
这些发现强调THEC是对心血管健康的重大威胁.

关键词:

细胞因子 (cytokines) 是一种细胞因子.电子烟是电子烟的产品.血小板是血小板的组成部分.第三方风险的第三方风险.血栓形成的原因是血栓形成.

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