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皮克丹 (Peucedanum japonicum Thunb.) 是一个日本的植物. 通过改善老年小鼠的线粒体功能来改善与年龄相关的肌肉损失

Young In Kim¹, Young-Soo Kim², Chang Hwa Jung^1,3

¹Aging Research Group, Korea Food Research Institute, 245, Nongsaengmyeong-Ro, Iseo-Myeon, Wanju-Gun, Jeollabuk-Do, 55365, Korea.

|February 17, 2026

概括

沿海猪 (PJ) 补充剂对抗老年小鼠与年龄相关的肌肉损失. 它增强了肌肉力量,质量和线粒体功能,表明了对萨尔科佩尼亚的治疗潜力.

科学领域:

老年学和肌肉生理学
营养药品和植物化学

背景情况:

与年龄相关的肌肉损失 (肉类衰老) 是一个严重的健康问题.
皮克丹 (Peucedanum japonicum Thunb.) 是一个日本的植物. (PJ),或沿海猪,在预防肌肉缩方面表现有前途.

研究的目的:

为了研究PJ在预防老年小鼠与年龄相关的肌肉损失方面的有效性.
阐明PJ对肌肉健康和线粒体功能影响的分子机制.

主要方法:

用PJ治疗老年小鼠的原发性髓母细胞.
给老年小鼠 (20个月大) 提供0.1%或0.2%PJ的食补充剂,持续8周.
评估肌肉力量,身体表现,肌肉质量,纤维类型分布,蛋白质降解和线粒体生物生成途径.

主要成果:

PJ治疗减弱了肌管缩,抑制了阿特罗基因表达,并防止了老年肌细胞中的纤维类型过渡.
在老年小鼠中,PJ补充改善了肌肉力量,耐力,步伐长度,瘦身量,肌肉重量和CSA.
通过PGC1α和Nrf1-Tfam通路,PJ增强了线粒体呼吸能力和生物发生,减少了蛋白质降解.

结论:

皮克丹 (Peucedanum japonicum Thunb.) 是一个日本的植物. 有效地抵抗与年龄相关的肌肉损失,并改善老年小鼠的线粒体功能.
活性化合物4-Caffeoylquinic酸 (4-CQA) 有助于PJ对肌肉健康的有益影响.
皮尔·杰伊 (PJ) 显示出在治疗缩症和相关的年龄相关肌肉衰退方面具有显著的治疗潜力.

关键词:

皮克丹 (Peucedanum japonicum Thunb.) 是一个日本的植物.衰老的衰老衰老的衰老线粒体功能障碍线粒体功能障碍蛋白质稳定性蛋白质稳定性萨尔科佩尼亚是什么意思萨尔科佩尼亚

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