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动脉样硬化心血管疾病中的残留脂质风险

Børge G Nordestgaard^1,2, Robert A Hegele^3,4

¹Department of Clinical Biochemistry, Copenhagen University Hospital - Herlev and Gentofte, Borgmester Ib Juuls vej 73, Herlev DK-2730, Denmark.

European heart journal

|February 17, 2026

概括

尽管优化了LDL胆固醇,但动脉样硬化心血管疾病 (ASCVD) 的残留风险仍然存在. 准非LDL胆固醇部分,如残留胆固醇和脂蛋白,对于更好的ASCVD风险管理至关重要.

科学领域:

心脏病学心脏病学
脂质学脂质学是指脂质学.
动脉样硬化研究动脉样硬化研究

背景情况:

动脉样硬化心血管疾病 (ASCVD) 中的残留脂质风险即使在优化低密度脂蛋白 (LDL) 胆固醇的情况下仍然存在.
非LDL胆固醇部分,包括残留胆固醇,脂蛋白a (Lp) [a]),阿波利波蛋白B (apoB) 和非高密度脂蛋白 (HDL) 胆固醇,越来越多地被认为是残留ASCVD风险的关键贡献者.

研究的目的:

审查对ASCVD残留脂质风险的不断变化的理解.
为临床医生提供关于管理非LDL脂质成分的实际指导.
讨论最近的治疗进展及其对优化脂质管理及其影响,除了减少LDL胆固醇之外.

主要方法:

关于脂质驱动动动脉动生成的最新研究的文献综述.
在ASCVD中分析残留胆固醇和Lp (a) 的病理生理作用.
探索针对非LDL脂质成分的新型治疗策略.

主要成果:

升高的残留胆固醇和LDL胆固醇有助于动脉壁胆固醇沉积和ASCVD.
脂蛋白 (Lp) 具有脂质成分和促炎性质,促进动脉样硬化斑块的发展.
脂蛋白Lp (a) 部分可能具有抗纤维解质和促血栓性质,可能会恶化ASCVD的结果.

结论:

优化脂质管理需要解决超出LDL的非LDL胆固醇部分.
针对残留胆固醇和Lp (a) 的新型治疗策略对于减轻残留ASCVD风险至关重要.
了解各种脂蛋白物种的复杂相互作用对于有效的ASCVD预防和治疗至关重要.

关键词:

血管蛋白类似蛋白质 (ANGPTL)乙类阿波利波蛋白 (B) 是一种阿波利波蛋白.在C-III的阿波利波蛋白中.纤维细胞生长因子21 (FGF21)胰腺炎是一种胰腺炎.富含甘油三酸的脂蛋白是什么

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