结构性大脑与整个阿尔茨海默病谱中的食欲和饮食障碍相关
Truelove Ejiofor1, Olajugba Oluwafunmilayo J2, Arushi Kala3
1Department of Psychology, Indira Gandhi National Open University.
Alzheimer disease and associated disorders
|February 17, 2026
概括
阿尔茨海默病 (AD) 中的食欲障碍与大脑变化有关,可能是早期神经退行症的信号. 这些饮食变化可能在认知能力下降之前出现,突出显示它们作为早期行为标志物的作用.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 神经精神症状,包括食欲和饮食障碍,在阿尔茨海默病 (AD) 中很常见.
- 这些症状可能先于认知障碍,这表明它们可能是阿尔茨海默病进展的早期指标.
- 了解这些干扰对于早期发现和管理AD至关重要.
研究的目的:
- 为了调查食欲和饮食障碍以及阿尔茨海默病中大脑结构之间的联系.
- 为了确定基线大脑结构是否预测了随着时间的推移食欲障碍的发展.
- 探索食欲障碍作为阿尔茨海默氏症相关大脑衰老的早期行为标志物的作用.
主要方法:
- 来自国家阿尔茨海默氏症协调中心 (NACC) 的7223名参与者的分析,使用统一数据集评估和MRI.
- 评估食欲和饮食障碍使用神经精神病查询问卷 (NPI).
- 使用多变量回归和离散时间生存模型进行横截面和纵向分析,以检查与大脑体积的关联.
主要成果:
- 9.4%的参与者出现食欲障碍,与增加的神经精神疾病负担和疾病严重程度相关.
- 全球灰色物质体积较低与食欲障碍有着强烈的交叉截面关联.
- 从长度上看,基线大脑结构仅在认知正常的个体中预测了发生的食欲障碍.
结论:
- 食欲障碍可能表明在阿尔茨海默病中存在扩散的神经退行性脆弱性.
- 这些饮食变化代表了与阿尔茨海默氏症相关的大脑衰老的潜在早期行为标志物.
- 对食欲障碍的进一步研究可以改善对AD的早期诊断和干预策略.
相关概念视频
01:26Alzheimer's Disease: Overview
1.8K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.8K
01:30Regulation of Food Intake
2.9K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
2.9K
01:37Neural Regulation
43.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.6K
01:22Alzheimer's Disease: Treatment
1.0K
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
1.0K
01:15Functional Brain Systems: Limbic System
7.7K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
7.7K
01:23Binge Eating Disorders
532
Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
532