在食道切除术期间胸腔消灭的营养和预后影响
Chia Liu1,2,3, Yi-Ying Lee1, Ling-I Chien4
1Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
在食道切除术期间的胸管消灭不会对食道癌症患者的长期营养或瘤结果产生负面影响. 在新辅助疗法患者的胸管切除显示了改善的生存率.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 胸管消灭 (TDO) 通过绑定或切除是用于食道切除癌症或胸腔.
- 对于TDO的长期营养和瘤影响尚不清楚.
研究的目的:
- 评估TDO在因食道癌而接受食道切除术的患者的营养和瘤结果.
主要方法:
- 从2016年1月到2024年5月,对82名TDO和313名非TDO患者进行了回顾性分析.
- 评估了实验室参数,CT衍生体质组成,营养指数,总生存率 (OS) 和无复发生存率 (RFS).
- 倾向性得分匹配创建了75名TDO和150名非TDO患者的组进行比较.
主要成果:
- 与非TDO相比,TDO增加了淋巴结产量,但没有影响胆胸部发病率,营养状况,身体组成,OS或RFS.
- 新辅助疗法 (NAT) 亚组在TDO患者的早期术后显示过渡性皮下脂肪损失,该损失在9-12个月内消失.
- 在NAT患者中,胸管切除与非切除相比,与改善3年后的OS (77.15%与57.25%) 和RFS (72.41%与48.08%) 相关.
结论:
- 在食道切除术期间的TDO对于食道癌患者的长期营养和瘤结果是安全的.
- 在接受TDO的NAT患者中,早期的术后皮下脂肪损失是暂时的.
- 在NAT患者的胸腔切除可以提高生存结果.
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