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Updated: Feb 19, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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循环素依赖激酶 (CDK) 7 抑制剂 BS-181 抑制了致病性Cryptococcus物种,导致G2/M 停止和拼接缺陷

Pooja Sethiya1,2, Desmarini Desmarini1,2, Bethany Bowring1,2

  • 1Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, NSW , Australia.

Virulence
|February 17, 2026
PubMed
概括

抗癌药物BS-181通过抑制循环素依赖性激酶7 (CDK7) 来表现出对Cryptococcus的抗真菌活性. 在临床前模型中,用BS-181和安波特乙的联合治疗提供了对真菌感染的增强保护.

关键词:
这是BS-181标准.这是一种CDK7抑制剂.克里普托科克斯 (Cryptococcus gattii) 是一个有毒的菌种.这是Cryptococcus neoformans的新型菌.这是一种抗真菌药物.细胞循环中的细胞循环.拼接 拼接 拼接 拼接转录 转录 是一种转录.翻译翻译翻译翻译翻译翻译

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