将癌细胞内在的驱动基因和外在的细胞-细胞通信与Driver2Comm相结合
Runzhi Xie1, Junping Li1, Yuxuan Hu1
1School of Computer Science and Technology, Xidian University, Xi'an, Shaanxi, China.
PLoS computational biology
|February 17, 2026
概括
Driver2Comm 识别了连接癌症驱动基因与瘤微环境中的细胞-细胞通信 (CCC) 的内在-外在途径. 这揭示了CCC的CCC.
科学领域:
- 癌症生物学 癌症生物学
- 计算生物学 计算生物学
- 免疫学 免疫学 免疫学
背景情况:
- 瘤进展受到癌细胞遗传学和瘤微环境 (TME) 的影响.
- 在TME中,细胞-细胞通信 (CCC),特别是免疫抑制,是关键的外部因素.
- 内在的癌症驱动因素和外在的CCC之间的相互作用仍然不太清楚.
研究的目的:
- 开发一个计算框架,Driver2Comm,用于系统地识别内在-外在 (IE) 路径.
- 为了将癌细胞驱动基因与TME中的相关CCC签名连接起来.
- 探索这些IE途径的功能作用和临床影响.
主要方法:
- 开发了Driver2Comm计算框架的开发.
- 应用Driver2Comm对来自各种癌症类型的单细胞和空间转录组数据.
- 对驱动基因相关的CCC特征进行免疫调节,转移和治疗反应的分析.
主要成果:
- Driver2Comm成功地确定了IE途径,将驱动器基因与CCC签名联系起来.
- 这些特征对于免疫调节,转移和预测治疗反应至关重要.
- 该框架揭示了更高层次的CCC模块和空间连贯的模式.
- 在预测患者存活率和对免疫检查点封锁的反应中证明了临床价值.
结论:
- Driver2Comm提供了一种可通用的方法,可以跨越癌症基因组学和瘤的细胞生态系统.
- 识别的CCC签名为TME重塑机制提供了洞察力.
- 这些发现支持生物标志物发现和开发新型组合疗法策略.
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