监管的重新布线推动了Bacillus subtilis的物种内部竞争
Margarita Kalamara1, Alistair Bonsall1, Jonathan Griffin1
1Division of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, Scotland.
PLoS genetics
|February 17, 2026
概括
破坏Bacillus subtilis的质量检测可以通过更快的生长或新的毒素来提高竞争力. 社区信号和个人优势之间的这种权衡塑造了微生物进化.
科学领域:
- 微生物生态学 微生物生态学
- 细菌遗传学 细菌遗传学
- 进化生物学 进化生物学
背景情况:
- 种内相互作用极大地影响微生物社区结构和进化.
- 在 Bacillus subtilis 中的定数感知系统调节合作和敌对行为,但竞争优势的机制仍然不清楚.
研究的目的:
- 为了研究"定决数感知调节在Bacillus subtilis菌株之间的竞争能力中的作用.
- 确定导致竞争性排斥的基因和分子机制.
主要方法:
- 多方面的方法,包括建模,突变分析,实验进化,家族基因调查和转录基因分析.
- 使用的 Bacillus subtilis 分离NCIB 3610和不同的野生分离物用于实验.
主要成果:
- 在NCIB 3610中的一个信号无响应的RapP-PhrP模块通过更快的增长赋予了竞争优势.
- 实验进化揭示了comP中反复发生的突变,导致与增长相关的竞争优势,模仿comP/comA删除.
- 遗传学分析显示,B. subtilis基因组中约16%的B. subtilis基因组中存在破坏性 comP 突变.
- 一种VII型分泌系统毒素被确定为一种额外的影响因素,影响超出增长率的竞争力.
结论:
- 质量检测途径的破坏为Bacillus subtilis提供了快速获得竞争优势的途径.
- 竞争结果受到增长速度和额外的效应因素的影响,例如七型分泌系统毒素.
- 在微生物群体中,共同信号与个体健康之间存在着根本的权衡.
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