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膀癌引起的心血管疾病死亡率:CAPG蛋白质的作用
Junwen Shen1,2, Zhucheng Zhao1,2, Zhaojun Li1,2
1The Department of Urology, The First Affiliated Hospital of Huzhou Normal College, Huzhou, Zhejiang, China.
PloS one
|February 17, 2026
概括
心血管疾病 (CVD) 显著增加了膀癌患者的死亡率. 膀癌中高CAPG蛋白表达通过影响心脏功能而提高心血管疾病风险,这表明CAPG是治疗点.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 分子生物学分子生物学
背景情况:
- 膀癌是一个重大的健康问题.
- 心血管疾病 (CVD) 是癌症患者死亡的主要原因.
- 了解膀癌和心血管疾病之间的联系对于改善患者的治疗结果至关重要.
研究的目的:
- 研究将膀癌与心血管疾病 (CVD) 死亡率联系在一起的机制.
- 为了确定参与膀癌与心力衰竭并发症的关键分子参与者.
- 探索减轻膀癌患者心血管疾病风险的潜在治疗点.
主要方法:
- 来自SEER数据库的大型队列 (140,760名患者) 的分析,以评估心血管疾病死亡风险.
- 交叉WGCNA和拉索回归的应用,以确定膀癌和心力衰竭之间的共享基因/蛋白质.
- 使用膀癌细胞系和心肌细胞进行体外研究,以评估蛋白质功能和药物疗效.
主要成果:
- 心血管疾病是膀癌患者的主要死亡原因,风险增加18%.
- 鉴定出SFRP1和CAPG是关键的血清蛋白,可以将膀癌与心力衰竭联系起来.
- CAPG蛋白表达对心肌细胞功能产生负面影响,是潜在的治疗点,SB525334显示抑制作用.
结论:
- 膀癌患者患心血管疾病死亡风险较高.
- 高CAPG蛋白表达是导致膀癌中心血管疾病风险的一个关键因素.
- 向CAPG是一个有希望的治疗策略,可以减少膀癌患者的心血管疾病相关死亡.
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