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Updated: Feb 19, 2026

Identifying Amino Acid Overproducers Using Rare-Codon-Rich Markers
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皮奇亚-CLM:基于Komagataella phaffii的语言模型的编码子优化管道

Harini Narayanan1, J Christopher Love1,2

  • 1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.

Proceedings of the National Academy of Sciences of the United States of America
|February 17, 2026
PubMed
概括

科学家们使用语言模型来改善酵母 Komagataella phaffii.酵母中的蛋白质生产. 这种编码子使用偏差优化增强了蛋白质产量高达三倍,超过了现有的工具.

关键词:
生物技术是生物技术.codon 使用偏差编码器解码器网络基因序列的基因序列是什么再组合蛋白质的生产.

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