一种与不育相关的长非编码RNA,参与蜜蜂种姓的确定和成年女王和工人的生育能力
Carlos A M Cardoso-Júnior1, Gustavo J Tibério1, Marina C Peruzzolo1
1Departamento de Biologia Celular e Molecular, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP 14049-900, Brazil.
概括
一种新发现的长非编码RNA (lncRNA),Incov1,通过调节卵巢编程细胞死亡,对维持蜜蜂工人不育是至关重要的. 这一发现揭示了昆虫社会复杂性的演变.
科学领域:
- 进化生物学是进化的生物学.
- 分子生物学分子生物学
- 昆虫学 昆虫学是一门学科.
背景情况:
- 昆虫的社交性涉及工人繁殖抑制,这是一个关键的进化过渡.
- 青年激素 (JH) 调节蜜蜂的种姓差异化和身份.
- 对于JH对昆虫卵巢的影响的分子机制尚未完全理解.
研究的目的:
- 为了研究蜜蜂工人不育的分子基础.
- 识别参与种姓决定和生殖抑制的新型分子参与者.
- 阐明长非编码RNAs (lncRNAs) 在昆虫社会进化中的作用.
主要方法:
- 分析蜜蜂卵巢中Incov1表达的不同种类和不同发育阶段.
- 研究JH水平,Incov1表达和卵巢编程细胞死亡之间的相关性.
- 检查饮食线索 (皇家果) 和社会信号 (皇后激素) 对Incov1表达和生育能力的影响.
主要成果:
- 一种新的长非编码RNA,Incov1,被确定,其表达与蜜蜂幼虫和成人的卵巢不育相关.
- 工虫幼虫的低JH水平导致Incov1的高表达和随后的卵巢编程细胞死亡.
- lncov1的表达受到环境线索的调节,如皇家和皇后激素,影响生殖能力.
结论:
- lncov1是一种关键的分子媒介,它将JH信号,环境线索和蜜蜂的繁殖抑制联系起来.
- 进化过程中,JH/lncov1通路在真社会蜜蜂中得到了保存,特别是在Apis.
- lncRNAs代表了昆虫社会复杂性和繁殖分工进化的关键组成部分.
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