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条纹生真菌破坏小麦阶段分离介导的免疫力,促进感染

Tong Yan^1,2, Jinren Zhao¹, Can Chen¹

¹State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi 712100, China.

Proceedings of the National Academy of Sciences of the United States of America

|February 17, 2026

概括

像条纹生真菌这样的植物病原体通过准液态相分离 (LLPS) 来破坏植物免疫力. 这项研究揭示了真菌如何使用效应剂Hasp170来分解宿主生物分子凝聚物,抑制植物防御.

科学领域:

植物病理学植物病理学
分子植物微生物相互作用.
生物化学生物化学

背景情况:

液-液相分离 (LLPS) 对植物应激反应至关重要.
在植物病原体相互作用中LLPS的作用尚不清楚.
植物免疫涉及复杂的分子信号通路.

研究的目的:

调查条纹菌是如何发生的 *Puccinia striiformis* f. sp. *tritici* (Pst) 操纵植物的免疫力.
阐明效应器Hasp170破坏宿主细胞过程的机制.
了解生物分子凝结物在小麦防御真菌病原体中的作用.

主要方法:

研究了Puccinia striiformis*效应剂Hasp170和小麦核蛋白TaPSTE之间的相互作用.
分析了TaPSTE在形成LLPS依赖生物分子凝聚物的作用.
研究了TaPSTE凝结物的转录因子TaNF-YC的招募.
评估了Hasp170结合对凝结物形成和下游免疫信号的影响.

主要成果:

条纹生真菌效应器Hasp170直接破坏小麦宿主LLPS.
Hasp170的目标是小麦蛋白TaPSTE的内在无序区域1 (IDR1).
结合Hasp170可以防止TaPSTE凝结物的形成和随后的TaNF-YC的招募.
这种干扰抑制了小麦的免疫力,促进了真菌感染.

结论:

病原体可以直接操纵宿主生物分子凝聚物作为一种毒性策略.
效应剂可以通过准LLPS来破坏植物免疫力.
了解这些机制为植物防御和疾病控制提供了见解.

关键词:

效应器效应器是一个有效的效应器.液态液态相隔离器液态液态相隔离器植物免疫力植物免疫力转录的LLPS可以使用.小麦条纹生的生.

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