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Updated: Feb 19, 2026

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一种犬类的PLP1误解变体在产妇和古典Pelizaeus-Merzbacher疾病中区分了寡细胞成熟

Rodrigo Gutierrez-Quintana1, Paul Montague2, Angie Rupp1

  • 1School of Biodiversity, One Health and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom.

Proceedings of the National Academy of Sciences of the United States of America
|February 17, 2026
PubMed
概括

英语可克西班牙犬的一种新型犬类白血病在人类中模仿了严重的Pelizaeus-Merzbacher病 (PMD). 这种由PLP1基因变异引起的自发性疾病为研究PMD机制和疗法提供了有价值的模型.

关键词:
动物模型动物模型狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗患有白血病的病例包括白血病.神经遗传学 神经遗传学精准医学是一门精准医学.

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