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在健康的中国成年人中确定脂溶性维生素的参考间隔:跨截面,多中心研究的研究方案
Zhong Liu1, Chenbing Liu1, Nan Li1
1Department of Health Management Center, The First Affiliated Hospital of Zhejiang University School of Medicine, 79 Qingchun Rd, Hangzhou, Zhejiang Province, 310003, China, 86 13957104885.
JMIR research protocols
|February 17, 2026
概括
这项研究在健康的中国成年人中确定了脂溶性维生素 (维生素A,D,E和K) 的关键参考间隔. 这些特定人口的范围将改善中国的营养评估和疾病预防.
科学领域:
- 营养生物化学 营养生物化学
- 临床化学 临床化学
- 公共卫生 公共卫生
背景情况:
- 脂溶性维生素 (FSV) 是重要的微量营养素,但它们在中国的评估通常使用西方参考间隔 (RIs).
- 在健康的中国成年人中,对所有四种FSV (A,D,E,K) 缺乏大规模研究.
- 营养状况和疾病风险受到FSV缺乏和过量的影响.
研究的目的:
- 在健康的中国成年人中为维生素A,D,E和K建立特定人群的参考间隔 (RIs).
- 为了支持对中国维生素状况的更准确的临床评估.
- 帮助预防与FSV失衡相关的疾病.
主要方法:
- 一项涉及20家中国医院10万名成年人的多中心,横截面研究.
- 标准化问卷,体检和采集血液样本.
- 通过液体染色学-并联质谱法量化FSV度的量化,在异常值被去除后,用百分位数方法确定RI.
主要成果:
- 截至2025年10月,已有13545名成年人入学,其中1690人符合入学标准.
- 招聘正在进行中,预计完成日期为2026年6月30日.
- 数据分析将为FSV度确定精确的2.5和97.5百分点极限.
结论:
- 这项研究将产生第一个大规模的,针对健康中国成年人群的FSV人口特异性参考间隔.
- 这些研究结果预计将在2027年公布,将为中国的临床营养评估提供关键证据.
- 改善的RI将增强与维生素状况相关的疾病预防策略.
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