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通过化基托桑纳米颗粒/基于凝的水凝增强了蒂莫洛尔酸的眼部输送
Mehdi Bayrami1, Marziyeh Fathi2, Elaheh Dalir Abdolahinia2
1Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
这项研究开发了硫化基托桑纳米颗粒 (TCS-NPs) 用于持续向眼部输送提摩洛尔酸 (TM). 该配方没有显著的毒性,并且有望为有效的药物输送提供潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 眼科医生 眼科 眼科
背景情况:
- 青光眼的治疗通常需要持续向眼睛输送药物.
- 传统的眼滴在眼睛的生物可用性和保留时间上有局限性.
- 基于纳米粒子的系统为改善眼部药物输送提供了潜力.
研究的目的:
- 准备和表征载有蒂醇马莱酸盐 (TM) 的提化奇托桑纳米颗粒 (TCS-NPs).
- 评估含有TM装载TCS-NP的凝 (GG) 水凝对眼部药物输送的潜力.
- 评估开发的配方的安全性和药物释放特性.
主要方法:
- 使用FT-IR和埃尔曼的方法证实了胆酸盐 (CS) 的化.
- 药物装载的纳米粒子 (NP) 通过溶解法进行制备.
- 评价了颗粒大小,多分散性指数 (PDI),泽塔潜力,捕获效率,风湿性质,形态学,药物释放和细胞毒性 (MTT测定).
主要成果:
- 优化TM载荷的TCS-NP显示颗粒大小为271.4nm,PDI为0.3和60.3%的捕获效率.
- TCS-NPs/GG配方对质性质的影响微不足道.
- 与自由NP相比,水凝中的NP释放药物较慢,没有显著的细胞毒性.
结论:
- 开发的化纳米颗粒 (TCS-NPs) 配方,含有分散在凝糖 (GG) 中的蒂摩洛尔酸 (TM),适用于眼部药物输送.
- 该TCS-NPs/GG系统显示了在眼睛中持续释放TM的潜力.
- 该配方是安全的,并显示了增强眼部治疗结果的希望.
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